Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | SCD | O00767 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329348 | 0.84 | NPC1 (0.70) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31317513 | 0.77 | TOP2A (0.54) | SMN1; SMN2MEN1KMT2APOLBRAB9A | |
| SCHEMBL31329341 | 0.75 | NPC1 (0.81) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31329343 | 0.73 | NPC1 (0.78) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31329354 | 0.73 | NPC1 (1.00) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1031135 | 0.72 | LMNA (0.48) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL13343587 | 0.72 | RXFP1 (0.56) | SMN1; SMN2MEN1KMT2ANPC1MAPT | |
| SCHEMBL3926899 | 0.72 | NPC1 (1.00) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31329345 | 0.72 | NPC1 (0.74) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3115005 | 0.71 | TYMS (0.72) | SMN1; SMN2POLBRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |