SCHEMBL31330174

SCHEMBL31330174

COC(=O)c1[nH]ccc1C#N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.42
CNR2 P34972 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 6/20 0.38
MAPT P10636 2/20 0.38
RXFP1 Q9HBX9 2/20 0.38
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALDH1A1 P00352 7/20 0.37
HPGD P15428 3/20 0.37
CRHBP P24387 2/20 0.37
CRHR2 Q13324 2/20 0.37
TDP1 Q9NUW8 1/20 0.36
KMT2A Q03164 2/20 0.36
HSD17B10 Q99714 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2941223 0.81 KDM4E (0.47) GAACYP1A2CYP2C9CYP2C19KDM4E
SCHEMBL30898400 0.77 MCL1 (0.39) KDM4EALDH1A1HPGDHSD17B10MCL1
SCHEMBL10636168 0.76 MCL1 (0.38) MAPTLMNAMCL1
SCHEMBL13729391 0.76 CNR2 (0.43) GAACNR2KDM4ELMNAALDH1A1
SCHEMBL69393 0.73 NR4A2 (0.44) GAACNR2KDM4ELMNAALDH1A1
SCHEMBL2937272 0.73 CA12 (0.47) GAACNR2KDM4EMAPTLMNA
SCHEMBL256714 0.73 CNR2 (0.44) GAACNR2CYP3A4KDM4ELMNA
SCHEMBL3942994 0.72 ALDH1A1 (0.42) GAAKDM4EMAPTRXFP1LMNA
SCHEMBL24840712 0.72 CNR2 (0.43) GAACNR2KDM4EMAPTLMNA
SCHEMBL21366811 0.72 CNR2 (0.43) GAACNR2KDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119371425-A Nitrogen-containing heterocyclic compound, preparation method and medical application thereof 中国医药研究开发中心有限公司 2025-01-28 CN disclosed