SCHEMBL31330263

SCHEMBL31330263

CNC(=O)CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]21

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 10/20 0.40
HTR2B P41595 10/20 0.40
HTR2A P28223 7/20 0.40
P2RX7 Q99572 2/20 0.38
TACR1 P25103 2/20 0.38
RORC P51449 1/20 0.38
CACNA1S Q13698 1/20 0.37
LIPE Q05469 1/20 0.37
KCNH2 Q12809 1/20 0.36
SCN5A Q14524 1/20 0.36
SCN9A Q15858 1/20 0.36
NAMPT P43490 1/20 0.35
USP30 Q70CQ3 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4471624 1.00 HTR2C (0.40) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4471627 1.00 HTR2C (0.40) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4467750 0.90 HTR2C (0.40) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4467749 0.90 HTR2C (0.40) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4465382 0.90 RORC (0.42) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4467242 0.89 HTR2C (0.43) HTR2CHTR2BHTR2AP2RX7CACNA1S
SCHEMBL4478197 0.88 HTR2C (0.43) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4478192 0.88 HTR2C (0.43) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4467969 0.86 HTR2C (0.44) HTR2CHTR2BHTR2AP2RX7TACR1
SCHEMBL4467971 0.86 HTR2C (0.44) HTR2CHTR2BHTR2AP2RX7TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4719393-A2 COMPOUNDS, COMPOSITIONS, AND METHODS Tenvie Therapeutics Inc. (US) 2026-04-08 EP claimed
WO-2024249929-A2 COMPOUNDS, COMPOSITIONS, AND METHODS NICO THERAPEUTICS, INC. (US) 2024-12-05 WO claimed
EP-4719393-A2 COMPOUNDS, COMPOSITIONS, AND METHODS Tenvie Therapeutics Inc. (US) 2026-04-08 EP disclosed
WO-2024249929-A2 COMPOUNDS, COMPOSITIONS, AND METHODS NICO THERAPEUTICS, INC. (US) 2024-12-05 WO disclosed