Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19680559 | 0.98 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1DRD2 | |
| SCHEMBL24001938 | 0.98 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1DRD2 | |
| SCHEMBL24001714 | 0.98 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1DRD2 | |
| Hydrochloric Acid SCHEMBL26989017 | 0.97 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1DRD2 | |
| SCHEMBL27074359 | 0.83 | DRD2 (0.42) | DRD2DRD3 | |
| SCHEMBL25170240 | 0.83 | DRD2 (0.42) | DRD2DRD3 | |
| SCHEMBL27166633 | 0.81 | — | — | |
| SCHEMBL24836005 | 0.79 | DRD2 (0.41) | DRD2DRD3 | |
| SCHEMBL24009697 | 0.79 | DRD2 (0.41) | DRD2DRD3 | |
| SCHEMBL30792980 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |