SCHEMBL31330871

SCHEMBL31330871

O=C1CCC(N2Cc3cc(OC[C@@H]4CCNC4)ccc3C2=O)C(=O)N1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 9/20 0.57
WIZ O95785 6/20 0.57
IKZF2 Q9UKS7 4/20 0.49
ITGB3 P05106 1/20 0.49
ITGA2B P08514 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20230997 0.94 CRBN (0.59) CRBNWIZIKZF2ITGB3ITGA2B
SCHEMBL31601608 0.94 CRBN (0.59) CRBNWIZIKZF2ITGB3ITGA2B
SCHEMBL24761939 0.88 WIZ (0.65) CRBNWIZIKZF2
SCHEMBL20046428 0.86 CRBN (0.59) CRBNWIZIKZF2
SCHEMBL22703780 0.85 WIZ (0.58) CRBNWIZIKZF2
SCHEMBL22962697 0.84 CRBN (0.66) CRBNWIZIKZF2
SCHEMBL31330802 0.83 CRBN (0.55) CRBN
SCHEMBL23350211 0.83 CRBN (0.63) CRBNWIZIKZF2
SCHEMBL20231670 0.83 CRBN (0.63) CRBNWIZIKZF2
SCHEMBL30744225 0.83 CRBN (0.63) CRBNWIZIKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025011623-A1 CYANOQUINOLINE-TARGETING PROTEIN DEGRADATION MOLECULE, PREPARATION METHOD THEREFOR AND USE THEREOF 上海壹迪生物技术有限公司 2025-01-16 WO disclosed