Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 16/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 13/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 13/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31331239 | 0.96 | PBRM1 (0.43) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL31331532 | 0.92 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4NR1I2BTK | |
| SCHEMBL31331283 | 0.89 | PBRM1 (0.47) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL31331277 | 0.88 | CRBN (0.36) | PBRM1SMARCA2SMARCA4NR1I2BTK | |
| SCHEMBL31331332 | 0.85 | PBRM1 (0.51) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL31330765 | 0.83 | PBRM1 (0.40) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25816414 | 0.81 | CRBN (0.48) | BTKCRBN | |
| SCHEMBL23331392 | 0.78 | CRBN (0.49) | PBRM1SMARCA2SMARCA4BTKCRBN | |
| SCHEMBL38664597 | 0.77 | PBRM1 (0.60) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18081213 | 0.77 | PBRM1 (0.69) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024245443-A1 | COMPOUND BASED ON OXOISOINDOLINYL SUBSTITUTED TETRAHYDRO-2-PYRIMIDONE, AND USE THEREOF | 标新生物医药科技(上海)有限公司 | 2024-12-05 | — | — | WO | claimed |
| WO-2024245443-A1 | COMPOUND BASED ON OXOISOINDOLINYL SUBSTITUTED TETRAHYDRO-2-PYRIMIDONE, AND USE THEREOF | 标新生物医药科技(上海)有限公司 | 2024-12-05 | — | — | WO | disclosed |