Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 7/20 | 0.48 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25815259 | 0.90 | CRBN (0.43) | CRBNDDB1IKZF3BTKDRD2 | |
| SCHEMBL25816399 | 0.83 | CRBN (0.45) | CRBNDDB1IKZF3BTKCDK9 | |
| SCHEMBL23331392 | 0.82 | CRBN (0.49) | CRBNBTKCDK9AREGFR | |
| SCHEMBL25816186 | 0.82 | CRBN (0.64) | CRBNDDB1IKZF3DRD2ADRA1D | |
| SCHEMBL23134695 | 0.81 | CRBN (0.58) | CRBNDDB1IKZF3BTKCDK9 | |
| SCHEMBL31331243 | 0.81 | PBRM1 (0.47) | CRBNBTK | |
| SCHEMBL23301268 | 0.81 | CRBN (0.45) | CRBNBTKCDK9AREGFR | |
| SCHEMBL29942891 | 0.81 | CRBN (0.45) | CRBNBTKCDK9AREGFR | |
| SCHEMBL25816369 | 0.81 | PBRM1 (0.56) | — | |
| SCHEMBL23134596 | 0.80 | CRBN (0.58) | CRBNDDB1IKZF3BTKCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |