Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 15/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133564 | 0.98 | POLB (0.48) | POLBPDE4AQPCTPDE4DPDE4B | |
| SCHEMBL3131100 | 0.95 | POLB (0.44) | POLBPDE4AQPCTPDE4DPDE4B | |
| SCHEMBL986245 | 0.87 | PDE4A (0.60) | POLBPDE4APDE4DPDE4BPDE4C | |
| SCHEMBL986248 | 0.87 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3118145 | 0.84 | POLB (0.47) | POLBPDE4AQPCTPDE4DPDE4B | |
| SCHEMBL1157332 | 0.84 | PDE4A (0.58) | POLBPDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3120566 | 0.84 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1157253 | 0.83 | TUBB4A (0.57) | POLBPDE4BALDH1A1MAPT | |
| SCHEMBL1157459 | 0.83 | POLB (0.55) | POLBPDE4AQPCTPDE4DPDE4B | |
| SCHEMBL1157608 | 0.82 | POLB (0.50) | POLBPDE4AQPCTPDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |