SCHEMBL31333360

SCHEMBL31333360

O=C(O)C1CCCC(Nc2ncc(Cl)c(-c3cccc(-n4ccccc4=O)c3)n2)C1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPK3 P27361 1/20 0.48
SYK P43405 2/20 0.46
MAPK1 P28482 11/20 0.43
ADORA1 P30542 1/20 0.42
ROCK2 O75116 2/20 0.42
ROCK1 Q13464 2/20 0.42
PCSK9 Q8NBP7 2/20 0.41
CCNT1 O60563 1/20 0.41
CDK7 P50613 1/20 0.41
CDK9 P50750 1/20 0.41
CCNH P51946 1/20 0.41
MNAT1 P51948 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334678 0.92 SYK (0.48) MAPK3SYKMAPK1ADORA1ROCK2
SCHEMBL31334882 0.91 SYK (0.43) MAPK3SYKMAPK1ROCK2ROCK1
SCHEMBL31333670 0.91 SYK (0.43) MAPK3SYKMAPK1ROCK2ROCK1
SCHEMBL31333586 0.90 SYK (0.46) MAPK3SYKMAPK1ADORA1ROCK2
SCHEMBL31333683 0.90 SYK (0.46) MAPK3SYKMAPK1ADORA1ROCK2
SCHEMBL31333264 0.90 SYK (0.46) MAPK3SYKMAPK1ADORA1ROCK2
SCHEMBL31333369 0.89 MAPK3 (0.44) MAPK3MAPK1ADORA1ROCK2ROCK1
SCHEMBL31334779 0.86 MAPK3 (0.56) MAPK3MAPK1ADORA1CCNT1CDK7
SCHEMBL31334595 0.86 MAPK3 (0.56) MAPK3MAPK1ADORA1CCNT1CDK7
SCHEMBL31333846 0.86 MAPK3 (0.56) MAPK3MAPK1ADORA1CCNT1CDK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed