SCHEMBL31333552

SCHEMBL31333552

O=C1CCC(Nc2ccc(C3CCN([C@H]4CC[C@H](NC(=O)[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(N8CCCCC8)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 8/20 0.34
CRBN Q96SW2 8/20 0.34
CCNT1 O60563 2/20 0.34
CCNA2 P20248 2/20 0.34
CDK2 P24941 2/20 0.34
CDK9 P50750 2/20 0.34
EGFR P00533 2/20 0.33
LCK P06239 2/20 0.33
BTK Q06187 2/20 0.33
PIK3CD O00329 2/20 0.33
CSF1R P07333 2/20 0.33
CDK4 P11802 2/20 0.33
CDK6 Q00534 2/20 0.33
SYK P43405 1/20 0.33
ABL1 P00519 2/20 0.33
JAK3 P52333 2/20 0.32
VCP P55072 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334447 1.00 DDB1 (0.34) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334658 0.94 JAK2 (0.37) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31333972 0.94 JAK2 (0.37) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334833 0.93 SYK (0.36) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31335116 0.93 SYK (0.36) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334917 0.93 SYK (0.36) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334331 0.93 SYK (0.36) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334706 0.92 MEN1 (0.37) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31333687 0.92 MEN1 (0.37) DDB1CRBNCCNT1CCNA2CDK2
SCHEMBL31334619 0.92 DDB1 (0.35) DDB1CRBNCCNT1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed