SCHEMBL31334833

SCHEMBL31334833

O=C1CCC(Nc2ccc(C3CCN([C@H]4CC[C@H](NC(=O)[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(N8CCCCC8=O)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SYK P43405 5/20 0.36
HRH3 Q9Y5N1 1/20 0.33
NPY5R Q15761 3/20 0.32
DDB1 Q16531 5/20 0.32
CRBN Q96SW2 5/20 0.32
PIK3CD O00329 2/20 0.32
CSF1R P07333 2/20 0.32
CDK4 P11802 2/20 0.32
CDK6 Q00534 2/20 0.32
CCNT1 O60563 1/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CDK9 P50750 1/20 0.32
FPR2 P25090 1/20 0.32
MAPK1 P28482 1/20 0.31
LIPG Q9Y5X9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31335116 1.00 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334331 1.00 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334917 1.00 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334447 0.93 DDB1 (0.34) SYKDDB1CRBNPIK3CDCSF1R
SCHEMBL31333552 0.93 DDB1 (0.34) SYKDDB1CRBNPIK3CDCSF1R
SCHEMBL31333225 0.92 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334216 0.92 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334073 0.92 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31333440 0.92 SYK (0.36) SYKHRH3NPY5RDDB1CRBN
SCHEMBL31334699 0.92 CCNA2 (0.34) DDB1CRBNPIK3CDCSF1RCDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed