SCHEMBL31333766

SCHEMBL31333766

O=C(CBr)N1CCC[C@H](Nc2ncc(Cl)c(-c3cccc(-c4ccccc4)c3)n2)C1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
JUN P05412 2/20 0.51
CDK2 P24941 2/20 0.51
MAPK8 P45983 2/20 0.51
MAPK9 P45984 2/20 0.51
MAPK10 P53779 2/20 0.51
MAPK1 P28482 16/20 0.51
MAPK3 P27361 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334187 1.00 JUN (0.51) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31333189 0.89 MAPK8 (0.52) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31333385 0.89 MAPK8 (0.52) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31333325 0.88 MAPK3 (0.58) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31334934 0.88 MAPK3 (0.58) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31333392 0.85 MAPK10 (0.51) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31334669 0.83 USP30 (0.59) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31333309 0.83 USP30 (0.59) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31334224 0.82 MAPK1 (0.49) JUNCDK2MAPK8MAPK9MAPK10
SCHEMBL31335001 0.80 MAPK8 (0.51) JUNCDK2MAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed