SCHEMBL31334134

SCHEMBL31334134

NC(=O)[C@H]1CC[C@H](Nc2ncc(F)c(-c3cccc(C4(O)CCC4)n3)n2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK3 P27361 2/20 0.39
MAPK6 Q16659 1/20 0.37
CDK2 P24941 2/20 0.36
CDK1 P06493 1/20 0.36
CDK4 P11802 1/20 0.36
CCND1 P24385 1/20 0.36
CCNT1 O60563 2/20 0.36
ABL1 P00519 2/20 0.36
MAPK8 P45983 4/20 0.35
SYK P43405 2/20 0.35
MAPK9 P45984 1/20 0.34
GSK3A P49840 1/20 0.34
CCNK O75909 1/20 0.34
CSNK1A1 P48729 1/20 0.34
CDK7 P50613 1/20 0.34
CDK9 P50750 1/20 0.34
CDK13 Q14004 1/20 0.34
CDK12 Q9NYV4 1/20 0.34
JUN P05412 1/20 0.34
MAPK10 P53779 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333506 0.92 ABL1 (0.36) CDK2CDK1CDK4CCND1CCNT1
SCHEMBL31333730 0.89 PDGFRB (0.37) MAPK6CDK2CDK1CDK4CCND1
SCHEMBL31334640 0.83 DYRK2 (0.38) MAPK3MAPK6CDK2CDK1ABL1
SCHEMBL31333789 0.83 DYRK2 (0.38) MAPK3MAPK6CDK2CDK1ABL1
SCHEMBL31334634 0.77 CDK2 (0.39) MAPK3MAPK6CDK2CDK1CDK4
SCHEMBL31334189 0.76 SYK (0.44) MAPK3MAPK6CDK2CDK1CDK4
SCHEMBL31334181 0.76 SYK (0.44) MAPK3MAPK6CDK2CDK1CDK4
SCHEMBL31333834 0.75 ADORA1 (0.46) MAPK3MAPK6CDK2CDK1MAPK8
SCHEMBL31333197 0.73 MAPK3 (0.41) MAPK3MAPK6CDK2CDK1CDK4
SCHEMBL31333785 0.72 PIM1 (0.36) ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed