SCHEMBL31334205

SCHEMBL31334205

O=C1CCC(Nc2ccc(N3CCN([C@H]4CC[C@H](C(=O)N[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(C8CC8)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 5/20 0.36
CRBN Q96SW2 5/20 0.36
SYK P43405 1/20 0.35
SIK1 P57059 2/20 0.34
SIK2 Q9H0K1 2/20 0.34
SIK3 Q9Y2K2 2/20 0.34
WEE1 P30291 1/20 0.34
CDK4 P11802 3/20 0.34
CDK6 Q00534 3/20 0.34
CSF1R P07333 2/20 0.34
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
CCNT1 O60563 2/20 0.33
CDK9 P50750 2/20 0.33
CCND1 P24385 1/20 0.33
PIK3CD O00329 1/20 0.33
BTK Q06187 1/20 0.32
CYP46A1 Q9Y6A2 1/20 0.32
CCNK O75909 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334505 1.00 DDB1 (0.36) DDB1CRBNSYKSIK1SIK2
SCHEMBL31334524 0.96 CDK4 (0.36) DDB1CRBNSYKSIK1SIK2
SCHEMBL31333493 0.95 CDK4 (0.36) DDB1CRBNSYKSIK1SIK2
SCHEMBL31335019 0.94 MEN1 (0.39) DDB1CRBNSYKSIK1SIK2
SCHEMBL31334478 0.94 MEN1 (0.39) DDB1CRBNSYKSIK1SIK2
SCHEMBL31334765 0.92 DDB1 (0.34) DDB1CRBNCDK4CDK6CSF1R
SCHEMBL31333502 0.92 DDB1 (0.34) DDB1CRBNCDK4CDK6CSF1R
SCHEMBL31333687 0.91 MEN1 (0.37) DDB1CRBNSYKSIK1SIK2
SCHEMBL31334706 0.91 MEN1 (0.37) DDB1CRBNSYKSIK1SIK2
SCHEMBL31335054 0.90 DDB1 (0.34) DDB1CRBNSYKSIK1SIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed