SCHEMBL31334765

SCHEMBL31334765

O=C1CCC(Nc2ccc(C3CCN([C@H]4CC[C@H](NC(=O)[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(C8CC8)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 9/20 0.34
CRBN Q96SW2 9/20 0.34
CSF1R P07333 5/20 0.33
CDK4 P11802 5/20 0.33
CDK6 Q00534 5/20 0.33
PIK3CD O00329 3/20 0.33
MAPK1 P28482 1/20 0.33
CCNA2 P20248 2/20 0.33
CDK2 P24941 2/20 0.33
CDK9 P50750 2/20 0.33
CCNT1 O60563 1/20 0.33
KDR P35968 1/20 0.32
JAK3 P52333 2/20 0.32
BTK Q06187 2/20 0.32
EGFR P00533 2/20 0.32
LCK P06239 2/20 0.32
CCNK O75909 1/20 0.32
CDK7 P50613 1/20 0.32
CCNH P51946 1/20 0.32
CDK5 Q00535 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333502 1.00 DDB1 (0.34) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334716 0.94 DDB1 (0.35) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334619 0.94 DDB1 (0.35) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334205 0.92 DDB1 (0.36) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334505 0.92 DDB1 (0.36) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334524 0.91 CDK4 (0.36) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334447 0.90 DDB1 (0.34) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31333552 0.90 DDB1 (0.34) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31333493 0.90 CDK4 (0.36) DDB1CRBNCSF1RCDK4CDK6
SCHEMBL31334009 0.90 MAPK1 (0.34) DDB1CRBNCSF1RCDK4CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed