SCHEMBL31334390

SCHEMBL31334390

CC(=O)N1CCC[C@H](Nc2ncc(Cl)c(-c3ccnc(-c4ccc(F)cc4)c3)n2)C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK3 P27361 3/20 0.49
MAPK1 P28482 9/20 0.47
JAK3 P52333 2/20 0.46
BTK Q06187 1/20 0.46
MAPK8 P45983 6/20 0.45
MAPK10 P53779 5/20 0.45
CDK2 P24941 4/20 0.45
MAPK9 P45984 3/20 0.45
JUN P05412 2/20 0.45
MAPK14 Q16539 3/20 0.44
PRKD3 O94806 1/20 0.43
MAP4K4 O95819 1/20 0.43
CSNK1A1 P48729 1/20 0.43
CSNK1D P48730 1/20 0.43
GSK3A P49840 1/20 0.43
GSK3B P49841 1/20 0.43
CSNK1G2 P78368 1/20 0.43
TAOK1 Q7L7X3 1/20 0.43
MINK1 Q8N4C8 1/20 0.43
PRKD2 Q9BZL6 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334227 0.90 MAPK3 (0.55) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31333913 0.90 MAPK1 (0.53) MAPK3MAPK1MAPK8CDK2MAPK9
SCHEMBL31334728 0.89 MAPK3 (0.53) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31334299 0.86 MAPK3 (0.52) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31334826 0.83 MAPK1 (0.45) MAPK1MAPK8MAPK10MAPK9MAPK14
SCHEMBL31334238 0.82 MAPK3 (0.49) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31334934 0.82 MAPK3 (0.58) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31333325 0.82 MAPK3 (0.58) MAPK3MAPK1JAK3BTKMAPK8
SCHEMBL31334188 0.79 CCNT1 (0.44) MAPK1MAPK14GSK3AGSK3B
SCHEMBL31333335 0.79 CDK2 (0.56) MAPK3MAPK1MAPK8MAPK10CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed