SCHEMBL31334506

SCHEMBL31334506

NC(=O)[C@H]1CC[C@H](Nc2ncc(F)c(-c3cccc(-n4cc(C(F)(F)F)ccc4=O)c3)n2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK3 P27361 2/20 0.40
CDK2 P24941 4/20 0.39
CCNA2 P20248 2/20 0.39
KDM1A O60341 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
CCNA1 P78396 1/20 0.39
BRAF P15056 1/20 0.39
EIF2AK4 Q9P2K8 1/20 0.38
MAPK1 P28482 5/20 0.37
CCR6 P51684 1/20 0.37
SYK P43405 2/20 0.37
MAPK6 Q16659 1/20 0.36
TYK2 P29597 1/20 0.36
CCNE1 P24864 2/20 0.36
CCNB2 O95067 1/20 0.36
CCNE2 O96020 1/20 0.36
CDK1 P06493 1/20 0.36
CCNB1 P14635 1/20 0.36
CDK5 Q00535 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333236 0.93 SYK (0.38) MAPK3CDK2CCNA2CCNA1BRAF
SCHEMBL31333877 0.92 CDK2 (0.40) MAPK3CDK2CCNA2KDM1AMAOA
SCHEMBL31334023 0.91 MAPK1 (0.39) MAPK3CDK2CCNA2CCNA1BRAF
SCHEMBL31334568 0.89 KDM1A (0.39) MAPK3CDK2CCNA2KDM1AMAOA
SCHEMBL31333244 0.89 MAPK6 (0.41) MAPK3CDK2CCNA2CCNA1BRAF
SCHEMBL31334709 0.87 SYK (0.48) MAPK3CDK2CCNA2CCNA1MAPK1
SCHEMBL31334896 0.87 SYK (0.48) MAPK3CDK2CCNA2CCNA1MAPK1
SCHEMBL31333858 0.86 MAPK3 (0.41) MAPK3CDK2CCNA2CCNA1MAPK1
SCHEMBL31334253 0.81 IRAK4 (0.40) MAPK3CDK2CCNA2MAPK1SYK
SCHEMBL31335020 0.81 IRAK4 (0.40) MAPK3CDK2CCNA2MAPK1SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed