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SCHEMBL31334654

SCHEMBL31334654

O=C1CCC(N2Cc3cc(OC4CCN(CCC5CCN(C(=O)C6CCCC(Nc7ncc(Cl)c(-c8cccc(-c9ccccc9)c8)n7)C6)CC5)CC4)ccc3C2=O)C(=O)N1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 11/20 0.41
▸ IKZF1 Q13422 2/20 0.39
▸ IKZF2 Q9UKS7 3/20 0.39
▸ BTK Q06187 1/20 0.39
▸ CRBN Q96SW2 3/20 0.38
▸ CDK12 Q9NYV4 1/20 0.38
▸ ESR1 P03372 1/20 0.37
▸ CSNK1A1 P48729 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334745 0.95 MAPK1 (0.42) MAPK1IKZF1IKZF2BTKCRBN
SCHEMBL31333691 0.95 MAPK1 (0.42) MAPK1IKZF1IKZF2BTKCRBN
SCHEMBL31334853 0.93 MAPK1 (0.43) MAPK1IKZF2
SCHEMBL31333647 0.92 MAPK1 (0.44) MAPK1BTK
SCHEMBL31333218 0.91 IKZF1 (0.49) MAPK1IKZF1IKZF2CRBN
SCHEMBL31333199 0.90 MAPK1 (0.42) MAPK1IKZF1BTK
SCHEMBL31333659 0.87 MAPK1 (0.44) MAPK1IKZF1
SCHEMBL31333787 0.86 IKZF1 (0.52) IKZF1IKZF2CRBN
SCHEMBL31334252 0.86 IKZF2 (0.51) MAPK1IKZF1IKZF2
SCHEMBL31334935 0.86 MAPK1 (0.44) MAPK1IKZF2BTKCRBNESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed