SCHEMBL31334705

SCHEMBL31334705

CC(C)(C)OC(=O)C1CCN(C2CCN(c3ccc(NC4CCC(=O)NC4=O)cc3F)CC2(F)F)CC1

nearest known ligand 0.45

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.45
DDB1 Q16531 18/20 0.45
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334701 1.00 CRBN (0.45) CRBNDDB1CYP3A4
SCHEMBL25175940 0.91 CRBN (0.53) CRBNDDB1
SCHEMBL31333722 0.90 CRBN (0.44) CRBNDDB1CYP3A4
SCHEMBL31333765 0.89 CRBN (0.49) CRBNDDB1
SCHEMBL31333472 0.88 CYP3A4 (0.44) CRBNDDB1CYP3A4
SCHEMBL30255557 0.85 DDB1 (0.55) CRBNDDB1CYP3A4
SCHEMBL30255508 0.85 DDB1 (0.55) CRBNDDB1CYP3A4
SCHEMBL29554940 0.85 DDB1 (0.55) CRBNDDB1CYP3A4
SCHEMBL31333617 0.85 CRBN (0.45) CRBNDDB1CYP3A4
SCHEMBL31333970 0.84 CRBN (0.51) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed