SCHEMBL31334774

SCHEMBL31334774

O=C1CCC(Nc2ccc(N3CCC(N4CCC(NC(=O)[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(N8CCCCC8=O)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 2/20 0.36
CSF1R P07333 1/20 0.36
CDK6 Q00534 1/20 0.36
SYK P43405 5/20 0.35
FPR2 P25090 1/20 0.34
SIK1 P57059 2/20 0.32
SIK2 Q9H0K1 2/20 0.32
SIK3 Q9Y2K2 2/20 0.32
DDB1 Q16531 2/20 0.32
CRBN Q96SW2 2/20 0.32
CCNT1 O60563 3/20 0.32
CDK9 P50750 3/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
CCND1 P24385 1/20 0.32
AXL P30530 2/20 0.32
HRH3 Q9Y5N1 1/20 0.32
CCNA2 P20248 2/20 0.31
CDK2 P24941 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333276 0.98 CDK4 (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31333440 0.96 SYK (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31334216 0.96 SYK (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31334073 0.96 SYK (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31333225 0.96 SYK (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31334989 0.93 CDK4 (0.38) CDK4CSF1RCDK6SYKSIK1
SCHEMBL31333720 0.92 CDK4 (0.36) CDK4CSF1RCDK6SYKSIK1
SCHEMBL31333635 0.92 CDK4 (0.38) CDK4CSF1RCDK6SIK1SIK2
SCHEMBL31334917 0.92 SYK (0.36) CDK4CSF1RCDK6SYKFPR2
SCHEMBL31335116 0.92 SYK (0.36) CDK4CSF1RCDK6SYKFPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed