Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinimide SCHEMBL30804677 | 0.73 | CRBN (0.65) | CRBNDDB1ALDH1A1KDM4EMAPT | |
| SCHEMBL11591540 | 0.71 | NOTUM (0.40) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| Acetic Acid SCHEMBL28337387 | 0.69 | CRBN (0.68) | CRBNDDB1ALDH1A1MAPT | |
| Acetic Acid SCHEMBL27810357 | 0.67 | BRD4 (0.43) | ALDH1A1KDM4EHPGDGAAMAPT | |
| Succinimide SCHEMBL28297707 | 0.66 | CRBN (0.61) | CRBNDDB1ALDH1A1KDM4EMAPT | |
| Succinimide SCHEMBL28348066 | 0.66 | CRBN (0.52) | CRBNDDB1KDM4E | |
| Succinimide SCHEMBL29278585 | 0.66 | CRBN (0.52) | CRBNDDB1KDM4E | |
| Acetic Acid SCHEMBL30741425 | 0.64 | CRBN (0.43) | CRBNDDB1ALDH1A1KDM4E | |
| Acetic Acid SCHEMBL27607093 | 0.64 | CRBN (0.77) | CRBNALDH1A1GAAMAPT | |
| SCHEMBL31058804 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120202200-A | Oxo-isoindolinyl substituted tetrahydropyrimidinedione-based compounds and applications thereof | 标新生物医药科技(上海)有限公司 | 2025-06-24 | — | — | CN | disclosed |
| WO-2024245443-A1 | COMPOUND BASED ON OXOISOINDOLINYL SUBSTITUTED TETRAHYDRO-2-PYRIMIDONE, AND USE THEREOF | 标新生物医药科技(上海)有限公司 | 2024-12-05 | — | — | WO | disclosed |