Sugi Predict

Sugi Predict / Compounds / SCHEMBL3133524

SCHEMBL3133524

SCHEMBL3133524

COc1ccc(Cn2cnc3c(NC4CC4)nc(C(F)(F)F)nc32)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNE1 P24864 2/20 0.53
▸ CDK2 P24941 2/20 0.53
▸ PDGFRA P16234 1/20 0.53
▸ YTHDC1 Q96MU7 3/20 0.52
▸ CNR2 P34972 2/20 0.51
▸ PDE4A P27815 4/20 0.49
▸ PDE4B Q07343 4/20 0.49
▸ PDE4C Q08493 4/20 0.49
▸ PDE4D Q08499 4/20 0.49
▸ PDE5A O76074 1/20 0.49
▸ PDE1A P54750 1/20 0.49
▸ PDE1B Q01064 1/20 0.49
▸ PDE1C Q14123 1/20 0.49
▸ CTSL P07711 3/20 0.48
▸ PDE3B Q13370 1/20 0.47
▸ PDE3A Q14432 1/20 0.47
▸ CTSB P07858 1/20 0.46
▸ CCNE2 O96020 1/20 0.44
▸ NR3C1 P04150 1/20 0.43
▸ CDK1 P06493 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3137739 0.90 PDE4A (0.58) CCNE1CDK2PDGFRAYTHDC1CNR2
SCHEMBL3137209 0.89 YTHDC1 (0.57) CCNE1CDK2PDGFRAYTHDC1PDE4A
SCHEMBL3141176 0.89 YTHDC1 (0.55) CCNE1CDK2PDGFRAYTHDC1CNR2
SCHEMBL3136346 0.89 PDE4A (0.52) CCNE1CDK2PDGFRAYTHDC1CNR2
SCHEMBL3131755 0.88 YTHDC1 (0.51) CCNE1CDK2PDGFRAYTHDC1PDE4A
SCHEMBL3133601 0.88 YTHDC1 (0.56) CCNE1CDK2PDGFRAYTHDC1PDE4A
SCHEMBL3130331 0.88 YTHDC1 (0.56) CCNE1CDK2PDGFRAYTHDC1PDE4A
SCHEMBL3128053 0.88 YTHDC1 (0.61) CCNE1CDK2PDGFRAYTHDC1CNR2
SCHEMBL3142237 0.87 YTHDC1 (0.53) CCNE1CDK2PDGFRAYTHDC1CNR2
SCHEMBL3133681 0.86 PDE4A (0.63) CCNE1CDK2PDGFRAYTHDC1PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100010020-A1 PHOSPHODIESTERASE 4 INHIBITORS LIU RUIPING 2010-01-14 — — US claimed
CN-100439370-C Trifluoromethylpurines as phosphodiesterase 4 inhibitors MEMORY PHARM CORP (US) 2008-12-03 — — CN claimed
US-20080119495-A1 PHOSPHODIESTERASE 4 INHIBITORS LIU RUIPING 2008-05-22 — — US claimed
US-7342021-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. (US) 2008-03-11 — — US claimed
US-20040242598-A1 Phosphodiesterase 4 inhibitors LIU RUIPING (US) 2004-12-02 — — US claimed
CN-1501927-A Trifluoromethylpurines as phosphodiesterase 4 inhibitors 记忆药物公司 2004-06-02 — — CN claimed
US-20030045533-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. 2003-03-06 — — US claimed
US-20100010020-A1 PHOSPHODIESTERASE 4 INHIBITORS LIU RUIPING 2010-01-14 — — US disclosed
US-20100004236-A1 PHOSPHODIESTERASE 4 INHIBITORS TEHIM ASHOK 2010-01-07 — — US disclosed
EP-1529049-B1 DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARM CORP (US) 2009-11-18 — — EP disclosed
US-20080139583-A1 PHOSPHODIESTERASE 4 INHIBITORS TEHIM ASHOK 2008-06-12 — — US disclosed
US-20080119495-A1 PHOSPHODIESTERASE 4 INHIBITORS LIU RUIPING 2008-05-22 — — US disclosed
US-7342021-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. (US) 2008-03-11 — — US disclosed
US-7332486-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. (US) 2008-02-19 — — US disclosed
US-20070093510-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. (US) 2007-04-26 — — US disclosed
CN-1688580-A 2-Trifluoromethyl-6-aminopurine derivatives as phosphodiesterase 4 inhibitors MEMORY PHARM CORP (US) 2005-10-26 — — CN disclosed
US-20040242598-A1 Phosphodiesterase 4 inhibitors LIU RUIPING (US) 2004-12-02 — — US disclosed
EP-1383767-A1 TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceutical Corporation (US) 2004-01-28 — — EP disclosed
US-20030045533-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORP. 2003-03-06 — — US disclosed
WO-2002098878-A1 TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2002-12-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093510-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE3B, PDE3A CCNE1 2248/4885CDK2 853/4885PDGFRA 597/4885
US-20080139583-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE3B, PDE3A CCNE1 2248/4885CDK2 853/4885PDGFRA 597/4885
US-20030045533-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE3A, PDE3B CCNE1 1968/4885CDK2 1035/4885PDGFRA 987/4885
US-20100004236-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE3B, PDE3A CCNE1 2248/4885CDK2 853/4885PDGFRA 597/4885
US-20040242598-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE3A, PDE3B CCNE1 1968/4885CDK2 1035/4885PDGFRA 987/4885
US-20080119495-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE3B, PDE3A CCNE1 2248/4885CDK2 853/4885PDGFRA 597/4885
US-20100010020-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE3B, PDE3A CCNE1 2248/4885CDK2 853/4885PDGFRA 597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.