⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255886 | 0.89 | — | — | |
| SCHEMBL841758 | 0.89 | — | — | |
| SCHEMBL1618587 | 0.89 | — | — | |
| SCHEMBL5137565 | 0.89 | — | — | |
| SCHEMBL42403 | 0.88 | — | — | |
| Water SCHEMBL1078570 | 0.84 | — | — | |
| SCHEMBL7225807 | 0.82 | — | — | |
| SCHEMBL4006109 | 0.82 | — | — | |
| Lithium Ion SCHEMBL6753893 | 0.82 | — | — | |
| SCHEMBL8936989 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150306027-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | NESTLÉ SKIN HEALTH SA (CH) | 2015-10-29 | — | — | US | disclosed |
| US-20150306124-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | NESTLÉ SKIN HEALTH SA (CH) | 2015-10-29 | — | — | US | disclosed |
| US-20140336139-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | NESTLÉ SKIN HEALTH SA (CH) | 2014-11-13 | — | — | US | disclosed |
| US-8858967-B2 | Dermatological cream-gels containing avermectin compounds | GALDERMA S.A. (CH) | 2014-10-14 | — | — | US | disclosed |
| US-8669233-B2 | Combination of compounds for treating or preventing skin diseases | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-03-11 | — | — | US | disclosed |
| US-8598129-B2 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions | GALDERMA S.A. (CH) | 2013-12-03 | — | — | US | disclosed |
| US-20130209381-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | GALDERMA S.A. (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8470788-B2 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions | GALDERMA S.A. (CH) | 2013-06-25 | — | — | US | disclosed |
| US-8415311-B2 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions | GALDERMA S.A. (CH) | 2013-04-09 | — | — | US | disclosed |
| US-20120258062-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | GALDERMA S.A. (CH) | 2012-10-11 | — | — | US | disclosed |
| US-20090281175-A1 | Avermectin compounds and treatment of dermatological disorders in humans therewith | GALDERMA S.A. (CH) | 2009-11-12 | — | — | US | disclosed |
| US-20090264378-A1 | Avermectin compounds and treatment of dermatological disorders in humans therewith | GALDERMA S.A. (CH) | 2009-10-22 | — | — | US | disclosed |
| US-20090264517-A1 | Milbemycin compounds and treatment of dermatological disorders in humans therewith | GALDERMA S.A. (CH) | 2009-10-22 | — | — | US | disclosed |
| US-20090264516-A1 | Milbemycin compounds and treatment of dermatological disorders in humans therewith | GALDERMA S.A. (CH) | 2009-10-22 | — | — | US | disclosed |
| US-20090252797-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | GALDERMA S.A. (CH) | 2009-10-08 | — | — | US | disclosed |
| US-20090233877-A1 | AVERMECTIN COMPOUNDS AND TREATMENT OF DERMATOLOGICAL DISORDERS THEREWITH | GALDERMA S.A. (CH) | 2009-09-17 | — | — | US | disclosed |
| US-20090227668-A1 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS | GALDERMA R&D (FR) | 2009-09-10 | — | — | US | disclosed |
| US-7550440-B2 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions | GALDERMA S.A. (CH) | 2009-06-23 | — | — | US | disclosed |
| US-20070116731-A1 | Dermatological cream-gels containing avermectin compounds | GALDERMA S.A. (CH) | 2007-05-24 | — | — | US | disclosed |
| US-20060100165-A1 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions | GALDERMA S.A. (CH) | 2006-05-11 | — | — | US | disclosed |