SCHEMBL31337331

SCHEMBL31337331

Nc1nc(Cl)nc2c1cnn2Cc1cc(Br)cc(CCn2cc(CO)ccc2=O)c1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.37
CYP2D6 P10635 4/20 0.37
HSP90AA1 P07900 3/20 0.35
TRAP1 Q12931 3/20 0.35
HSP90AB1 P08238 1/20 0.35
ADORA2A P29274 8/20 0.32
HDAC1 Q13547 4/20 0.31
HSP90B1 P14625 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31337335 0.91 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1HSP90AB1
SCHEMBL31337269 0.90 CYP3A4 (0.49) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31337273 0.90 CYP3A4 (0.36) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31356466 0.90 CYP3A4 (0.40) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31337326 0.89 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31337512 0.87 HSP90AA1 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1HSP90AB1
SCHEMBL31337355 0.87 HSP90AA1 (0.34) CYP3A4CYP2D6HSP90AA1TRAP1HSP90AB1
SCHEMBL31337262 0.82 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31337511 0.82 HSP90AA1 (0.36) CYP3A4CYP2D6HSP90AA1TRAP1HSP90AB1
SCHEMBL31337282 0.81 HSP90AA1 (0.38) CYP3A4CYP2D6HSP90AA1TRAP1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050636-A1 MACROCYCLIC PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2025-03-13 WO disclosed
CN-119552171-A Macrocyclic pyrazolopyrimidine compound and application thereof 浙江养生堂天然药物研究所有限公司 2025-03-04 CN disclosed