SCHEMBL31337262

SCHEMBL31337262

COc1ccc(Cn2ncc3c(N)nc(Cl)nc32)cc1CCn1cc(CO)ccc1=O

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.37
CYP2D6 P10635 4/20 0.37
SLC2A1 P11166 1/20 0.36
HSP90AA1 P07900 1/20 0.36
TRAP1 Q12931 1/20 0.36
RXFP1 Q9HBX9 1/20 0.34
ALDH1A1 P00352 2/20 0.33
PDE1A P54750 1/20 0.33
PDE1B Q01064 1/20 0.33
PDE1C Q14123 1/20 0.33
PKM P14618 1/20 0.32
PKLR P30613 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
YTHDC1 Q96MU7 1/20 0.32
ADORA2A P29274 3/20 0.32
ADORA1 P30542 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31337512 0.88 HSP90AA1 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31356452 0.87 SLC2A1 (0.35) CYP3A4CYP2D6SLC2A1HSP90AA1TRAP1
SCHEMBL31337326 0.86 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1ALDH1A1
SCHEMBL31337511 0.85 HSP90AA1 (0.36) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31356466 0.85 CYP3A4 (0.40) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31337467 0.84 SLC2A1 (0.43) CYP3A4CYP2D6SLC2A1HSP90AA1TRAP1
SCHEMBL31337335 0.82 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1PKM
SCHEMBL31337331 0.82 CYP3A4 (0.37) CYP3A4CYP2D6HSP90AA1TRAP1ADORA2A
SCHEMBL31356456 0.81 ALDH1A1 (0.43) CYP3A4CYP2D6SLC2A1HSP90AA1TRAP1
SCHEMBL31337269 0.80 CYP3A4 (0.49) CYP3A4CYP2D6HSP90AA1TRAP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050636-A1 MACROCYCLIC PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2025-03-13 WO disclosed
CN-119552171-A Macrocyclic pyrazolopyrimidine compound and application thereof 浙江养生堂天然药物研究所有限公司 2025-03-04 CN disclosed