Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.53 |
| ▸ | DRD3 | P35462 | 18/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453141 | 0.90 | HTR2A (0.53) | HTR2ADRD3HTR1A | |
| SCHEMBL3122831 | 0.88 | HTR2A (0.44) | HTR2ADRD3HTR1A | |
| SCHEMBL1970613 | 0.86 | DRD2 (0.52) | HTR2ADRD3HTR1A | |
| SCHEMBL13013912 | 0.85 | HTR2A (0.52) | HTR2ADRD3HTR1A | |
| SCHEMBL3453146 | 0.85 | HTR2A (0.52) | HTR2ADRD3HTR1A | |
| SCHEMBL14748241 | 0.85 | HTR2A (0.52) | HTR2ADRD3HTR1A | |
| SCHEMBL14748231 | 0.85 | HTR2A (0.51) | HTR2ADRD3HTR1A | |
| SCHEMBL3454011 | 0.84 | HTR2A (0.64) | HTR2ADRD3 | |
| SCHEMBL1966846 | 0.84 | HTR2A (0.64) | HTR2ADRD3 | |
| SCHEMBL3128925 | 0.84 | HTR2A (0.52) | HTR2ADRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | claimed |
| WO-2010031735-A1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |