SCHEMBL31347017

SCHEMBL31347017

COC(=O)c1cc(Cl)nc(CN)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
KDM4E B2RXH2 5/20 0.46
LOXL2 Q9Y4K0 2/20 0.45
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
TDP1 Q9NUW8 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
POLB P06746 2/20 0.41
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
NFKB1 P19838 1/20 0.41
XDH P47989 1/20 0.41
GFER P55789 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
FUT7 Q11130 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17113134 1.00 ALDH1A1 (0.47) ALDH1A1KDM4ELOXL2CA12CA1
Hydrochloric Acid SCHEMBL26107145 0.98 ALDH1A1 (0.46) ALDH1A1KDM4ELOXL2CA12CA1
SCHEMBL13350408 0.88 KDM4E (0.53) ALDH1A1KDM4ELOXL2CA12CA1
SCHEMBL4730272 0.87 ALDH1A1 (0.49) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL21158928 0.85 ALDH1A1 (0.48) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL3511223 0.85 ALDH1A1 (0.48) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL2718011 0.84 ALDH1A1 (0.47) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL31347123 0.84 ALDH1A1 (0.47) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL14377721 0.84 ALDH1A1 (0.47) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL9069519 0.83 KDM4E (0.49) ALDH1A1KDM4ELOXL2CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119585252-A Bicyclic heteroaryl containing compounds as IKZF2 degrading agents 翁科皮亚治疗公司和SK生命科学实验室 2025-03-07 CN disclosed