SCHEMBL31347553

SCHEMBL31347553

COc1ccc(C(O)CN)cc1N

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 3/20 0.66
BLM P54132 3/20 0.64
PMP22 Q01453 1/20 0.64
ADRA2A P08913 2/20 0.54
ADRA1A P35348 2/20 0.54
MAPT P10636 3/20 0.49
CYP3A4 P08684 3/20 0.49
APEX1 P27695 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
TAAR1 Q96RJ0 3/20 0.49
HPGD P15428 2/20 0.49
RECQL P46063 2/20 0.49
LMNA P02545 2/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
THRB P10828 2/20 0.49
KDM4E B2RXH2 2/20 0.49
ADRB2 P07550 1/20 0.49
ADRB1 P08588 1/20 0.49
ADORA3 P0DMS8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7147299 1.00 NFKB1 (0.66) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL15921910 0.86 NFKB1 (0.75) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL7148550 0.86 NFKB1 (0.75) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL1966507 0.86 NFKB1 (0.75) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL29633151 0.86 NFKB1 (0.75) NFKB1BLMPMP22ADRA2AADRA1A
Hydrochloric Acid SCHEMBL8904803 0.84 BLM (0.76) NFKB1BLMPMP22ADRA2AADRA1A
Normetanephrine Hydrochloride SCHEMBL11573078 0.83 NFKB1 (0.76) NFKB1BLMPMP22ADRA2AADRA1A
Normetanephrine Hydrochloride SCHEMBL7153624 0.83 NFKB1 (0.76) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL10935737 0.81 NFKB1 (0.64) NFKB1BLMPMP22ADRA2AADRA1A
SCHEMBL7150624 0.81 NFKB1 (0.64) NFKB1BLMPMP22ADRA2AADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119591621-A Novel ecteinascidin derivatives, preparation method and application thereof, antibody drug conjugate and application thereof 泰诚思(上海)生物医药有限公司 2025-03-11 CN disclosed