Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22299424 | 0.81 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL67636 | 0.81 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL68602 | 0.79 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL2612675 | 0.76 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL68113 | 0.73 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL6671494 | 0.72 | ALDH1A1 (0.40) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL5835789 | 0.70 | NOTUM (0.64) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL221250 | 0.70 | NOTUM (0.64) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL11329335 | 0.68 | KDM4E (0.45) | KDM4EHSD17B10ALDH1A1GLAALOX15 | |
| SCHEMBL13871254 | 0.68 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1GLAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2128160-B1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | UNIV DUISBURG ESSEN (DE) | 2010-07-14 | — | — | EP | disclosed |
| EP-2128160-A1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | Universität Duisburg-Essen (DE) | 2009-12-02 | — | — | EP | disclosed |
| US-5672705-A | ANTIISCHEMIC AGENTS TREATING NERVOUS SYSTEM DISORDERS, HUNTINGTON' DISEASE, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1997-09-30 | — | — | US | disclosed |
| WO-1997025329-A1 | 5H,10H-IMIDAZO[1,2-a]INDOLO[3,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |
| EP-0708778-B1 | IMIDAZO[1,2-A]PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1997-02-05 | — | — | EP | disclosed |
| EP-0708778-A1 | IMIDAZO[1,2-A]PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002602-A1 | IMIDAZO(1,2-A)PYRAZIN-4-ONE DERIVATIVES FOR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-01-26 | — | — | WO | disclosed |