Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138994 | 0.85 | MAPT (0.56) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3140335 | 0.85 | MAPT (0.60) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3140138 | 0.83 | MAPT (0.54) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3134626 | 0.82 | MAPT (0.53) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3139289 | 0.81 | MAPT (0.52) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3126799 | 0.81 | KMO (0.60) | MAPTL3MBTL1KMT2AMEN1NPC1 | |
| SCHEMBL3125866 | 0.80 | KMO (0.58) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3143961 | 0.77 | MEN1 (0.52) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3129059 | 0.77 | MAPT (0.52) | MAPTL3MBTL1KMT2AMEN1SCN9A | |
| SCHEMBL3125837 | 0.77 | SCN9A (0.55) | MAPTL3MBTL1KMT2AMEN1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265866-B1 | ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2010-07-21 | — | — | EP | claimed |