SCHEMBL31356459

SCHEMBL31356459

COC(=O)c1ccc(Br)c(COS(C)(=O)=O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.44
KDM4E B2RXH2 3/20 0.43
HSD17B10 Q99714 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CCR6 P51684 1/20 0.42
HKDC1 Q2TB90 1/20 0.42
HPGD P15428 5/20 0.42
MAPT P10636 3/20 0.42
ALDH1A1 P00352 3/20 0.42
CA12 O43570 5/20 0.41
CA1 P00915 5/20 0.41
CA2 P00918 5/20 0.41
CA9 Q16790 5/20 0.41
CA14 Q9ULX7 4/20 0.41
CA7 P43166 2/20 0.41
XDH P47989 1/20 0.41
POLB P06746 1/20 0.41
VCAM1 P19320 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.40
CYP1A2 P05177 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL256771 0.83 NOTUM (0.50) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL30622268 0.83 NOTUM (0.50) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL31385433 0.83 MAPT (0.50) KDM4EHSD17B10SMN1; SMN2HPGDMAPT
SCHEMBL31385413 0.83 RORC (0.44) KDM4EHSD17B10SMN1; SMN2HPGDMAPT
SCHEMBL2803953 0.82 NOTUM (0.47) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL213000 0.81 KDM4E (0.44) KDM4EHSD17B10SMN1; SMN2HPGDMAPT
SCHEMBL3180951 0.81 MAPT (0.48) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL2358109 0.80 NOTUM (0.53) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL409154 0.79 NOTUM (0.47) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6
SCHEMBL256770 0.79 NOTUM (0.51) NOTUMKDM4EHSD17B10SMN1; SMN2CCR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050636-A1 MACROCYCLIC PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2025-03-13 WO disclosed
WO-2025001407-A1 POLYARYL-CONTAINING MACROCYCLIC COMPOUNDS AND USES THEREOF 浙江养生堂天然药物研究所有限公司 2025-01-02 WO disclosed