Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MIF | P14174 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358677 | 0.87 | GSK3B (0.55) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358708 | 0.84 | MAPT (0.68) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358844 | 0.82 | MEN1 (0.60) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358656 | 0.81 | MAPT (0.71) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358700 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358698 | 0.79 | MAPT (0.61) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358714 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL31358692 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL25420537 | 0.77 | AKT1 (0.70) | ALDH1A1MAPTHPGDPOLBKDM4E | |
| SCHEMBL26168390 | 0.77 | AKT1 (0.70) | ALDH1A1MAPTHPGDPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | ALDH1A1 3926/4885MAPT 4688/4885HPGD 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.