Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.64 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.46 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876111 | 0.90 | PTPN5 (0.72) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL7876112 | 0.90 | PTPN5 (0.72) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL26168538 | 0.90 | PTPN5 (0.72) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL25218896 | 0.86 | PTPN5 (0.69) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL25246954 | 0.85 | PTPN5 (0.68) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL31358848 | 0.85 | PTPN5 (0.68) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL26168393 | 0.84 | PTPN22 (0.83) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL31358719 | 0.83 | PTPN5 (0.63) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL31358810 | 0.83 | PTPN5 (0.63) | PTPN5PTPN1PTPN7DUSP3PTPN22 | |
| SCHEMBL31358713 | 0.83 | PTPN5 (0.68) | PTPN5PTPN1PTPN7DUSP3PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | PTPN5 8/4885PTPN1 3/4885PTPN7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.