Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.63 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.63 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.63 |
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | LDHB | P07195 | 1/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MIF | P14174 | 3/20 | 0.49 |
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25420537 | 1.00 | AKT1 (0.70) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL26168390 | 1.00 | AKT1 (0.70) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358669 | 0.89 | PTPN5 (0.63) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358730 | 0.84 | POLB (0.57) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358785 | 0.83 | POLB (0.60) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358682 | 0.83 | PIM1 (0.59) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL26168567 | 0.83 | PIM1 (0.59) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL6720217 | 0.82 | AKT1 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358662 | 0.82 | AKT1 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL26168423 | 0.82 | AKT1 (0.67) | AKT1PTPN22PTPN5PTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | AKT1 194/4885PTPN22 5/4885PTPN5 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.