Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 1.00 |
| ▸ | PTPN22 | Q9Y2R2 | 6/20 | 0.70 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.70 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.70 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.70 |
| ▸ | LDHA | P00338 | 1/20 | 0.63 |
| ▸ | LDHB | P07195 | 1/20 | 0.63 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.63 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | PPM1G | O15355 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358662 | 1.00 | AKT1 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358731 | 0.87 | AKT1 (0.77) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358895 | 0.87 | AKT1 (0.77) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358841 | 0.85 | AKT1 (0.73) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25270155 | 0.83 | AKT1 (0.71) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25213499 | 0.83 | AKT1 (0.71) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25248130 | 0.82 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL14444606 | 0.82 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25248127 | 0.82 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25420537 | 0.82 | AKT1 (0.70) | AKT1PTPN22PTPN5PTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | SANFORD-BURNHAM RESEARCH INSTITUTE | 2012-07-26 | — | — | US | disclosed |
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | SANFORD-BURNHAM RESEARCH INSTITUTE | 2012-07-26 | — | — | US | disclosed |
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| EP-1802297-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION | BURNHAM INST (US) | 2011-03-30 | — | — | EP | disclosed |
| US-20100168162-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-07-01 | — | — | US | disclosed |
| US-20090312352-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-17 | — | — | US | disclosed |
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2009-05-21 | — | — | US | disclosed |
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2009-05-21 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | AKT1S1, AKT1, PIK3CA | AKT1 2/4885PTPN22 917/4885PTPN5 656/4885 |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | AKT1 964/4885PTPN22 3638/4885PTPN5 4472/4885 |
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | AKT1S1, AKT1, PIK3CA | AKT1 2/4885PTPN22 656/4885PTPN5 439/4885 |
| US-20090312352-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION | PTPRS, PTPRO, PTPN5 | AKT1 355/4885PTPN22 9/4885PTPN5 3/4885 |
| US-20100168162-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | AKT1S1, AKT1, PIK3CA | AKT1 2/4885PTPN22 855/4885PTPN5 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.