Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 3/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.53 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358687 | 0.83 | PTPN5 (0.66) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358789 | 0.83 | INSR (0.52) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358704 | 0.80 | PIK3CG (0.64) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358778 | 0.80 | KMT2A (0.52) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358810 | 0.79 | PTPN5 (0.63) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358770 | 0.78 | PTPN5 (0.64) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358836 | 0.78 | PTPN5 (0.59) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL25246954 | 0.78 | PTPN5 (0.68) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358848 | 0.78 | PTPN5 (0.68) | PTPN5DUSP3PTPN1PTPN7PTPN22 | |
| SCHEMBL31358703 | 0.78 | PTPN5 (0.64) | PTPN5DUSP3PTPN1PTPN7PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | PTPN5 8/4885DUSP3 43/4885PTPN1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.