Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | PRKX | P51817 | 2/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.46 |
| ▸ | STK3 | Q13188 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127193 | 0.79 | JAK2 (0.52) | JAK2CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL31361069 | 0.76 | CXCR2 (0.44) | CDK2ALDH1A1HTT | |
| SCHEMBL31361067 | 0.76 | CXCR2 (0.44) | CDK2ALDH1A1HTT | |
| SCHEMBL10168708 | 0.76 | CXCR2 (0.44) | CDK2ALDH1A1HTT | |
| SCHEMBL17069452 | 0.75 | JAK2 (0.46) | JAK2CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL31361062 | 0.72 | POLB (0.38) | JAK2MAP4K4SYKMAP4K2PKN2 | |
| SCHEMBL5026846 | 0.72 | JAK3 (0.50) | JAK2CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL17908134 | 0.70 | CDK19 (0.46) | JAK2CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL30544164 | 0.70 | POLB (0.42) | ROCK2TYK2 | |
| SCHEMBL28529103 | 0.70 | POLB (0.42) | ROCK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176820-A | Tricyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-12-24 | — | — | CN | disclosed |