Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.48 |
| ▸ | ITGAV | P06756 | 7/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.44 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.44 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13802930 | 0.88 | KMT2A (0.53) | RAB9AKMT2AGAAITGB3ITGA2B | |
| SCHEMBL5151576 | 0.88 | KMT2A (0.53) | RAB9AKMT2AGAAITGB3ITGA2B | |
| SCHEMBL3141349 | 0.87 | ITGB3 (0.58) | RAB9AKMT2AGAAITGB3ITGA2B | |
| SCHEMBL2889994 | 0.78 | KMT2A (0.58) | RAB9AKMT2AGAAEDNRA | |
| SCHEMBL6705540 | 0.78 | KMT2A (0.58) | RAB9AKMT2AGAAEDNRA | |
| SCHEMBL4381742 | 0.78 | EDNRA (0.48) | RAB9AKMT2AEDNRA | |
| SCHEMBL2857614 | 0.78 | EDNRA (0.48) | RAB9AKMT2AEDNRA | |
| SCHEMBL15238897 | 0.77 | KMT2A (0.59) | RAB9AKMT2AGAAITGB3ITGA2B | |
| SCHEMBL15239028 | 0.77 | KMT2A (0.59) | RAB9AKMT2AGAAITGB3ITGA2B | |
| SCHEMBL20976479 | 0.77 | KMT2A (0.59) | RAB9AKMT2AGAAITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079825-B1 | COMPOUNDS THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2010-07-21 | — | — | EP | disclosed |
| US-6262084-B1 | Compounds that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION | 2001-07-17 | — | — | US | disclosed |
| US-6096773-A | INHIBITOR OF BINDING OF INTEGRIN TO ITS RECEPTORS, SUCH AS (VASCULAR CELL ADHESION MOLECULE-1) AND FIBRONECTIN AND USEFUL FOR CONTROLLING THE DISEASES INDUCED BY BINDING | TEXAS BIOTECHNOLOGY CORPORATION, INC. (US) | 2000-08-01 | — | — | US | disclosed |