Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035925 | 0.88 | CACNA1B (0.62) | STSTGFBR1CACNA1BGPR119MMP13 | |
| SCHEMBL3131465 | 0.83 | TGFBR1 (0.56) | STSTGFBR1CACNA1BGPR119 | |
| SCHEMBL1498436 | 0.81 | STS (0.58) | STSTGFBR1CACNA1BGPR119NR1I2 | |
| SCHEMBL2191964 | 0.81 | CACNA1B (0.62) | STSTGFBR1CACNA1BGPR119NR1I2 | |
| SCHEMBL13932906 | 0.80 | CACNA1B (0.66) | STSTGFBR1CACNA1BGPR119NR1I2 | |
| SCHEMBL3031564 | 0.80 | CACNA1B (0.52) | STSTGFBR1CACNA1B | |
| SCHEMBL3136936 | 0.79 | CACNA1B (0.49) | CACNA1BNR1I2 | |
| SCHEMBL8240680 | 0.79 | STS (0.53) | STSTGFBR1CACNA1BGPR119NR1I2 | |
| SCHEMBL3123102 | 0.79 | CACNA1B (0.61) | CACNA1BNR1I2 | |
| SCHEMBL3129002 | 0.79 | CACNA1B (0.51) | CACNA1BNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205083-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009045382-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |