Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | SDHB | P21912 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276115 | 1.00 | CFTR (0.39) | CFTRSLC6A4SLC6A3AKR1C3AKR1C2 | |
| SCHEMBL17276219 | 0.81 | PDK2 (0.50) | SMN1; SMN2PDK2RBP4NOTUM | |
| SCHEMBL31367303 | 0.77 | PDK2 (0.46) | CFTRSLC6A4SLC6A3AKR1C3AKR1C2 | |
| SCHEMBL17276328 | 0.77 | PDK2 (0.46) | CFTRSLC6A4SLC6A3AKR1C3AKR1C2 | |
| SCHEMBL17276275 | 0.76 | PDK2 (0.45) | CFTRSLC6A4SLC6A3AKR1C3AKR1C2 | |
| SCHEMBL12389765 | 0.73 | PDK2 (0.48) | ALDH1A1HPGDSMN1; SMN2PDK2RBP4 | |
| SCHEMBL28133503 | 0.71 | PDK2 (0.36) | ALDH1A1HPGDPDK2RBP4LMNA | |
| SCHEMBL17276098 | 0.70 | NR4A2 (0.44) | CFTRSLC6A4SLC6A3AKR1C3AKR1C2 | |
| SCHEMBL28841543 | 0.70 | APP (0.41) | AKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL28134284 | 0.70 | HSD11B1 (0.40) | ALDH1A1HPGDNOTUMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145915-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |