Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TACR1 | P25103 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129391 | 0.92 | POLB (0.50) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL2808354 | 0.87 | ALDH1A1 (0.44) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3134693 | 0.86 | PHGDH (0.49) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3131744 | 0.85 | KDM4E (0.48) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3132930 | 0.83 | MAPT (0.47) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3129315 | 0.83 | POLB (0.47) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL4844573 | 0.83 | MAPT (0.53) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3129232 | 0.83 | MAPT (0.53) | POLBKDM4ETACR1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4846324 | 0.82 | MAPT (0.52) | POLBKDM4ETACR1MAPTALDH1A1 | |
| SCHEMBL3135648 | 0.80 | MAPT (0.53) | POLBKDM4ETACR1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699778-B1 | (4-PHENYLPIPERAZIN-1-YL)ACYLPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-07-14 | — | — | EP | disclosed |