SCHEMBL31373440

SCHEMBL31373440

COc1ccc2cc(NC(=O)c3ccc(Br)cc3N3CCC4(CC3)CC4)c(F)c(N3CCC(F)(F)CC3)c2n1

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748556 0.89 KIF18A (0.48) KIF18A
SCHEMBL31373529 0.89 KIF18A (0.48) KIF18A
SCHEMBL26650534 0.89 KIF18A (0.48) KIF18A
SCHEMBL30748549 0.88 KIF18A (0.47) KIF18A
SCHEMBL26650726 0.88 KIF18A (0.47) KIF18A
SCHEMBL31373499 0.85 KIF18A (0.49) KIF18A
SCHEMBL31485257 0.85 KIF18A (0.71) KIF18A
SCHEMBL26650553 0.85 KIF18A (0.71) KIF18A
SCHEMBL22148435 0.80 KIF18A (0.70) KIF18A
SCHEMBL29370895 0.80 KIF18A (0.70) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119212988-A Kinesin KIF18A inhibitor and application thereof 上海湃隆生物科技有限公司 2024-12-27 — — CN disclosed
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