SCHEMBL31373449

SCHEMBL31373449

CCOC(=O)c1cc2ccncc2c(Cl)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.45
CASP1 P29466 1/20 0.45
KDM5A P29375 1/20 0.43
KDM5B Q9UGL1 1/20 0.43
ALDH1A1 P00352 4/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ELANE P08246 2/20 0.41
KMT2A Q03164 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MEN1 O00255 1/20 0.41
HPGD P15428 1/20 0.40
GABRP O00591 3/20 0.40
GABRD O14764 3/20 0.40
GABRA1 P14867 3/20 0.40
GABRB1 P18505 3/20 0.40
GABRG2 P18507 3/20 0.40
GABRB3 P28472 3/20 0.40
GABRA5 P31644 3/20 0.40
GABRA3 P34903 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL212240 1.00 CYP1A2 (0.45) CYP1A2CASP1KDM5AKDM5BALDH1A1
SCHEMBL23956778 0.89 KDM5A (0.46) CYP1A2CASP1KDM5AKDM5BALDH1A1
SCHEMBL162887 0.82 CYP1A2 (0.53) CYP1A2ALDH1A1SMN1; SMN2KMT2ANPC1
SCHEMBL23198535 0.80 ALDH1A1 (0.50) CYP1A2CASP1KDM5AKDM5BALDH1A1
SCHEMBL31254231 0.80 ALDH1A1 (0.50) CYP1A2CASP1KDM5AKDM5BALDH1A1
SCHEMBL25893827 0.80 CYP1A2 (0.43) CYP1A2ALDH1A1SMN1; SMN2KMT2ANPC1
SCHEMBL22392847 0.78 ALDH1A1 (0.61) CYP1A2ALDH1A1SMN1; SMN2ELANEGABRA1
SCHEMBL212070 0.78 KDM4E (0.42) ALDH1A1KMT2AMEN1KDM4EPOLB
SCHEMBL23202573 0.77 ALDH1A1 (0.47) CYP1A2CASP1KDM5AKDM5BALDH1A1
SCHEMBL30474276 0.77 ALDH1A1 (0.47) CYP1A2CASP1KDM5AKDM5BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119212988-A Kinesin KIF18A inhibitor and application thereof 上海湃隆生物科技有限公司 2024-12-27 CN disclosed