Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.33 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27035651 | 1.00 | JAK1 (0.42) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035557 | 0.85 | TEAD1 (0.55) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL30683313 | 0.84 | TEAD1 (0.37) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035687 | 0.84 | TEAD1 (0.37) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035562 | 0.82 | JAK2 (0.39) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035626 | 0.80 | JAK2 (0.39) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL30683308 | 0.80 | JAK2 (0.39) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035649 | 0.79 | JAK2 (0.38) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL30683302 | 0.79 | JAK2 (0.38) | JAK1TYK2JAK2JAK3TEAD1 | |
| SCHEMBL27035551 | 0.79 | TYK2 (0.38) | JAK1TYK2JAK2JAK3TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119497708-A | TEAD inhibitors and methods of use | 思博睿生物探索公司 | 2025-02-21 | — | — | CN | disclosed |