Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27035576 | 0.91 | TEAD1 (0.52) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL31374685 | 0.85 | JAK1 (0.42) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035687 | 0.85 | TEAD1 (0.37) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035651 | 0.85 | JAK1 (0.42) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL30683313 | 0.85 | TEAD1 (0.37) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035555 | 0.84 | TEAD1 (0.58) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035701 | 0.83 | TEAD1 (0.58) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035578 | 0.82 | TEAD1 (0.53) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035551 | 0.81 | TYK2 (0.38) | TEAD1YAP1JAK1TYK2JAK2 | |
| SCHEMBL27035562 | 0.81 | JAK2 (0.39) | TEAD1YAP1JAK1TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558485-A1 | TEAD INHIBITORS AND METHODS OF USE | Sporos Biodiscovery, Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| CN-119497708-A | TEAD inhibitors and methods of use | 思博睿生物探索公司 | 2025-02-21 | — | — | CN | disclosed |
| WO-2024020350-A1 | TEAD INHIBITORS AND METHODS OF USE | SPOROS BIODISCOVERY, INC. (US) | 2024-01-25 | — | — | WO | disclosed |