SCHEMBL313747

SCHEMBL313747

CCCC(=O)OC1C(O)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cnc2c(=O)[nH]c(N)nc21

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 7/20 0.62
TAS1R3 Q7RTX0 1/20 0.53
TAS1R1 Q7RTX1 1/20 0.53
HINT1 P49773 8/20 0.51
HPGD P15428 1/20 0.49
GSK3A P49840 2/20 0.47
RPS6KA3 P51812 2/20 0.47
MAPK14 Q16539 2/20 0.47
NT5E P21589 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL313746 1.00 TYMP (0.62) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL7201354 0.95 TYMP (0.62) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL16702978 0.90 TYMP (0.68) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL1738400 0.90 TYMP (0.68) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL18042134 0.90 TYMP (0.68) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL21905181 0.89 TYMP (0.67) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL6420722 0.88 TYMP (0.79) TYMPHINT1HPGDGSK3ARPS6KA3
SCHEMBL17223100 0.87 TYMP (0.64) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL6460952 0.86 TYMP (0.63) TYMPTAS1R3TAS1R1HINT1HPGD
SCHEMBL7647098 0.85 TAAR1 (0.47) TYMPTAS1R3TAS1R1HINT1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 649 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2270024-B1 Antisense modulation of superoxide dismutase 1, soluble expression IONIS PHARMACEUTICALS INC (US) 2018-10-24 EP disclosed
US-20180094260-A1 EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS KASTLE THERAPEUTICS, LLC (US) 2018-04-05 US disclosed
US-20170355986-A1 ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION KASTLE THERAPEUTICS, LLC (US) 2017-12-14 US disclosed
US-9476051-B2 Antisense modulation of superoxide dismutase 1, soluble expression IONIS PHARMACEUTICALS, INC. (US) 2016-10-25 US disclosed
US-20150232838-A1 EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS COMERICA BANK 2015-08-20 US disclosed
US-20150167008-A1 ANTISENSE MODULATION OF SUPEROXIDE DISMUTASE 1, SOLUBLE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2015-06-18 US disclosed
EP-2365094-B1 Antisense modulation of PTP1B expression ISIS PHARMACEUTICALS INC (US) 2015-04-22 EP disclosed
US-20150105440-A1 ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION GENZYME CORPORATION (US) 2015-04-16 US disclosed
EP-2174945-B1 Antisense modulation of apolipoprotein B expression GENZYME CORP (US) 2015-04-08 EP disclosed
US-8993529-B2 Antisense modulation of superoxide dismutase 1, soluble expression ISIS PHARMACEUTICALS, INC. (US) 2015-03-31 US disclosed
US-5985663-A AN ANTISENSE COMPOUND 8 TO 30 NUCLEOBASES IN LENGTH TARGETED TO A 5' UNTRANSLATED REGION OR 3' UNTRANSLATED REGION OF A NUCLEIC ACID ENCODING HUMAN INTERLEUKIN-15 ISIS PHARMACEUTICALS INC. (US) 1999-11-16 US disclosed
US-5981732-A ANTISENSE OLIGONUCLEOTIDES WHICH TARGET THE EXPRESSION OF A G PROTEIN ISIS PHARMACEUTICALS INC. (US) 1999-11-09 US disclosed
US-5977341-A Antisense modulation of inhibitor-kappa B kinase-beta expression ISIS PHARMACEUTICALS INC. (US) 1999-11-02 US disclosed
US-5962673-A ANTISENSE AGENT 8 TO 30 NUCLEOBASES IN LENGTH; FOR DIAGNOSIS AND TREATMENT OF ASTHMA, MYASTHENIA GRAVIS, GRAVES' DISEASE, ALLOGRAFT REJECTION, PSORIASIS AND OTHERS; ANTITUMOR/ ANTIPROLIFERATIVE/ANTIDIABETIC/ANTIARTHRITIC AGENTS ISIS PHARMACEUTICALS INC. (US) 1999-10-05 US disclosed
US-5958771-A OLIGONUCLEOTIDE FROM 8 TO 30 NUCLEOTIDES IN LENGTH; FOR DIAGNOSIS AND THERAPY; ANTITUMOR/ANTIINFLAMMATORY AGENTS ISIS PHARMACEUTICALS, INC. (US) 1999-09-28 US disclosed
US-5958772-A TARGETS TO NUCLEIC ACID MOLECULE ENCODING HUMAN CELLULAR INHIBITORS OF APOTOPSIS-1 ISIS PHARMACEUTICALS INC. (US) 1999-09-28 US disclosed
US-5959097-A OLIGONUCLEOTIDE OF 8 TO 30 NUCLEOTIDES WHICH SUPPRESSES EXPRESSION OF SIGNAL TRANSDUCTION KINASE; FOR TREATMENT OF INFECTIONS; ANTIINFLAMMATORY/ANTITUMOR AGENTS ISIS PHARMACEUTICALS, INC. (US) 1999-09-28 US disclosed
US-5958773-A ANTISENSE COMPOUND 8 TO 30 NUCLEOTIDES IN LENGTH TARGETED TO A NUCLEIC ACID ENCODING HUMAN AKT-1, OF THE SERINE/THREONINE KINASE FAMILY INVOLVED IN SIGNALLING PATHWAYS; INHIBITING EXPRESSION OF AKT-1 WITH THE ANTISENSE COMPOUND ISIS PHARMACEUTICALS INC. (US) 1999-09-28 US disclosed
US-5951455-A OLIGONUCLEOTIDES, TARGETED TO NUCLEIC ACIDS WITH MODULATION AND EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1999-09-14 US disclosed
US-5948680-A ANTISENSE OLIGONUCLEOTIDE TARGETED TO NUCLEIC ACIDS ENCODING ELK-1; ANTIPROLIFERATIVE AGENTS ISIS PHARMACEUTICALS INC. (US) 1999-09-07 US disclosed