SCHEMBL6420722

SCHEMBL6420722

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(=O)[nH]c(N)nc43)[C@H](O)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 9/20 0.79
HINT1 P49773 4/20 0.60
GSK3A P49840 2/20 0.58
RPS6KA3 P51812 2/20 0.58
MAPK14 Q16539 2/20 0.58
NT5E P21589 1/20 0.57
HPGD P15428 1/20 0.56
ADORA1 P30542 2/20 0.54
PNP P00491 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5960204 0.94 TYMP (0.69) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL10904155 0.94 TYMP (0.76) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL1904550 0.94 TYMP (0.76) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL18042134 0.93 TYMP (0.68) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL1738400 0.93 TYMP (0.68) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL16702978 0.93 TYMP (0.68) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL21905181 0.92 TYMP (0.67) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL28827051 0.91 TYMP (0.65) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL17223100 0.90 TYMP (0.64) TYMPHINT1GSK3ARPS6KA3MAPK14
SCHEMBL8958859 0.90 TYMP (0.64) TYMPHINT1GSK3ARPS6KA3MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567009-A2 ANTISENSE MODULATION OF NOTCH (DROSOPHILA) HOMOLOG 4 EXPRESSION Isis Pharmaceuticals, Inc. (US) 2005-08-31 EP disclosed
EP-1501854-A2 ANTISENSE MODULATION OF HMGI-C EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2005-02-02 EP disclosed
EP-1501941-A1 ANTISENSE MODULATION OF JAGGED 2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2005-02-02 EP disclosed
EP-1461419-A2 ANTISENSE MODULATION OF PHOSPHOLIPID SCRAMBLASE 3 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-09-29 EP disclosed
EP-1461461-A2 ANTISENSE MODULATION OF CD81 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-09-29 EP disclosed
EP-1461349-A2 ANTISENSE MODULATION OF MHC CLASS II TRANSACTIVATOR EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-09-29 EP disclosed
EP-1451363-A2 ANTISENSE MODULATION OF THYROID HORMONE RECEPTOR INTERACTOR 6 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-09-01 EP disclosed
EP-1436310-A1 ANTISENSE MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-07-14 EP disclosed
EP-1417216-A2 ANTISENSE MODULATION OF BCL2-ASSOCIATED X PROTEIN EXPRESSION ISIS Pharmaceuticals, Inc. (US) 2004-05-12 EP disclosed
EP-1417339-A2 ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-05-12 EP disclosed
WO-2003000656-A2 ANTISENSE MODULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR II EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2003-01-03 WO disclosed
WO-2002097108-A2 ANTISENSE MODULATION OF DUAL SPECIFIC PHOSPHATASE 5 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-12-05 WO disclosed
WO-2002092855-A1 ANTISENSE MODULATION OF HELICASE-MOI EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-11-21 WO disclosed
WO-2002088392-A1 ANTISENSE MODULATION OF GU PROTEIN EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-11-07 WO disclosed
WO-2002088162-A1 ANTISENSE MODULATION OF INTERFERON GAMMA RECEPTOR 1 EXPRESSION ISIS PHARMACEUTICALS, INC (US) 2002-11-07 WO disclosed
WO-2002088393-A1 ANTISENSE MODULATION OF TUMOR NECROSIS FACTOR RECEPTOR 2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-11-07 WO disclosed
WO-2002024720-A1 ANTISENSE MODULATION OF CASPASE 2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-03-28 WO disclosed
WO-2002020546-A1 ANTISENSE MODULATION OF PHOSPHORYLASE KINASE ALPHA 1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-03-14 WO disclosed
WO-2001071008-A1 ANTISENSE INHIBITION OF ADAM10 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2001-09-27 WO disclosed
WO-2000050440-A1 ANTISENSE MODULATION OF Smad5 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-08-31 WO disclosed