Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 14/20 | 0.67 |
| ▸ | LATS2 | Q9NRM7 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26177142 | 0.80 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL31375141 | 0.80 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL29649757 | 0.79 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL20547766 | 0.79 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL413342 | 0.78 | CYP1A2 (1.00) | ALDH1A1LMNACYP1A2CYP3A4CLK4 | |
| SCHEMBL26177169 | 0.78 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL14344353 | 0.78 | LATS1 (0.89) | LATS1LATS2ALDH1A1LMNACYP1A2 | |
| SCHEMBL26177149 | 0.77 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL14344372 | 0.77 | TGFBR1 (0.80) | LATS1LATS2ALDH1A1LMNACYP1A2 | |
| SCHEMBL20547808 | 0.76 | LATS1 (1.00) | LATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | disclosed |