Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.82 |
| ▸ | DDX5 | P17844 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | HBB | P68871 | 2/20 | 0.76 |
| ▸ | CASP1 | P29466 | 1/20 | 0.76 |
| ▸ | CASP7 | P55210 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | GLA | P06280 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | STAT6 | P42226 | 1/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.75 |
| ▸ | GMNN | O75496 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30805390 | 0.94 | TOP1 (0.78) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16649109 | 0.94 | TOP1 (0.78) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22598074 | 0.94 | TOP1 (0.78) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL34463611 | 0.94 | TOP1 (0.78) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31726257 | 0.93 | TOP1 (0.80) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30538213 | 0.93 | TOP1 (0.82) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26405346 | 0.93 | TOP1 (0.82) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16648871 | 0.91 | TOP1 (0.74) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31726297 | 0.91 | TOP1 (0.74) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30805404 | 0.91 | TOP1 (0.74) | TOP1DDX5MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022001864-A1 | ANTIBODY-DRUG CONJUGATE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 昆山新蕴达生物科技有限公司 | 2022-01-06 | — | — | WO | disclosed |
| EP-2197279-B1 | C10-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS INC (US) | 2017-01-18 | — | — | EP | disclosed |
| EP-2197879-B1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS INC (US) | 2014-01-22 | — | — | EP | disclosed |
| EP-2007386-B1 | CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2197279-A1 | C10-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-06-23 | — | — | EP | disclosed |
| EP-2197879-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-06-23 | — | — | EP | disclosed |
| US-7687487-B2 | Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687496-B2 | C7-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687497-B2 | C10-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| WO-2009051578-A1 | C10-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009051580-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |
| US-20090099224-A1 | C7- substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099166-A1 | C10-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| EP-2007386-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| WO-2007123995-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, “FLIPPED” LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099166-A1 | C10-substituted camptothecin analogs | ABCB1, ABCC1, TOP1 | TOP1 3/4885DDX5 2479/4885MEN1 1708/4885 |
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | PAICS, FAU, FOLR1 | TOP1 26/4885DDX5 1866/4885MEN1 141/4885 |
| US-20090099224-A1 | C7- substituted camptothecin analogs | ABCB1, ABCC1, ABCG2 | TOP1 7/4885DDX5 1541/4885MEN1 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.