Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983292 | 0.84 | HDAC1 (0.39) | HDAC1HDAC8HDAC6KCNH2OPRL1 | |
| SCHEMBL30983249 | 0.80 | MEN1 (0.51) | HDAC1HDAC8HDAC6CXCR4HRH3 | |
| SCHEMBL31380351 | 0.79 | HDAC1 (0.39) | HDAC1HDAC8HDAC6KDM4EHDAC5 | |
| SCHEMBL30983305 | 0.78 | CHEK1 (0.42) | HDAC1HDAC8HDAC6KCNH2ABL1 | |
| SCHEMBL30983220 | 0.76 | HDAC1 (0.50) | HDAC1HDAC8HDAC6CXCR4HDAC5 | |
| SCHEMBL31380388 | 0.76 | HDAC1 (0.50) | HDAC1HDAC8HDAC6CXCR4HDAC5 | |
| SCHEMBL31380316 | 0.75 | HDAC1 (0.43) | HDAC1HDAC8HDAC6CXCR4HDAC5 | |
| SCHEMBL31187808 | 0.75 | TRPV3 (0.37) | HDAC1HDAC8HDAC6ABL1 | |
| SCHEMBL31064618 | 0.74 | STIM1 (0.39) | HTTKDM4E | |
| SCHEMBL24247920 | 0.74 | CXCR4 (0.51) | CXCR4KCNH2HRH3OPRL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |